Open access
Aug 2026
HNF4α promotes urate excretion by activating ABCG2 and mediates the anti-hyperuricemic effect of saffron floral bio-residue.
The HNF4α/ABCG2 axis is identified as a potential pathway governing renal urate excretion and positions HNF4α as a promising therapeutic target for HUA, providing a novel mechanistic basis for the development of natural product-based therapies against HUA.
Na Chen, Jun Xiang, Jiaqi Li et al.
· Phytomedicine · 0 citations