Review
Jul 2026
Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches.
Structural biology and signaling principles are integrated to explain how MDA5 architecture governs interactions with dsRNA and type 1 interferon (T1-IFN) outputs and outline therapeutic entry points that preserve antiviral defense while constraining chronic T1-IFN signaling.
Opeoluwa F. Iwaloye, Clayton E. Mathews, Dan-Meng Li
· Journal of Interferon and Cy... · 0 citations