Elucidating the Therapeutic Mechanism of Puhuaiyin in Rosacea: An Integrated Study Based on Network Pharmacology, Bioinformatics, Molecular Docking, and Molecular Dynamics Simulations.
BACKGROUND Rosacea is a chronic inflammatory skin disorder with limited therapeutic options. Puhuaiyin (PHY), a traditional Chinese medicinal formula, shows clinical efficacy, but its multi-component mechanisms remain unclear. METHODS Chemical constituents of PHY were identified by UPLC-Q-TOF-MS. Network pharmacology...