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Author

Dana Laor Bar-Yosef

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Review Open access Sep 2026

Functional abiotic metabolite assembly hypothesis for the early events in the origin of life

The RNA world hypothesis provides a compelling framework for the emergence of life, yet a fundamental gap remains between simple abiotic molecules and complex functional RNA polymers. Here, we propose the Functional Abiotic Metabolite Assembly hypothesis, in which simple prebiotically abundant molecules, particularly a...

P. Chakraborty, Cheng-Qian Yuan, Shon A. Levkovich et al. · 0 citations
Aug 2026

Early Hetero-Oligomerization of Tau Fragments Redirects Cofactor-Free Tau Assembly and Fibril Morphology

Early tau assembly intermediates are increasingly recognized as bioactive species that govern downstream aggregation and cellular dysfunction, yet it remains unresolved whether distinct tau fragments directly interact during these early stages to redirect pathway selection. Here, we use a cofactor-free two-peptide mo...

Happy Abena Safoah, Sarah Hirschbeck, Jie Chen et al. · 0 citations

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