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Dana Paquin

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Open access Oct 2026

Significance filtering induces denominator selection bias in local genetic correlation: closed-form characterisation, a gate-aware correction, and an applicability diagnostic

Local genetic correlation is estimated as a ratio of a local genetic covariance to the geometric mean of two local heritabilities. LAVA, the standard implementation, returns that ratio only where both traits clear a univariate heritability test at P < 0.05, a rule its documentation presents as a stabiliser. We show tha...

Dana Paquin, R. Jain · 0 citations

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