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Dana Yahia

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Open access Sep 2026

10- Circumventing the Thermal Degradation of Atorvastatin Calcium to Facilitate its Production by Melt Extrusion

Atorvastatin (ATV), a widely used lipid-lowering agent, faces significant formulation challenges due to its poor aqueous solubility and thermal instability. This study aims to develop a melt-extrudable formulation of ATV while mitigating the risk of its thermal degradation. Through the use of hot-melt extrusion (HME) m...

Jehad Nasereddin, Roza Younis, Jameel S. AljaririAlhesan et al. · 0 citations

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