10- Circumventing the Thermal Degradation of Atorvastatin Calcium to Facilitate its Production by Melt Extrusion
Atorvastatin (ATV), a widely used lipid-lowering agent, faces significant formulation challenges due to its poor aqueous solubility and thermal instability. This study aims to develop a melt-extrudable formulation of ATV while mitigating the risk of its thermal degradation. Through the use of hot-melt extrusion (HME) m...