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Daniel A. Mordes

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Open access Sep 2026

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

It is established that low-twist filaments, which include over 75% of disease-associated Lewy aSyn amyloids, share a common structural core with high-twist forms and are the predominant aSyn species in samples that engage in templated infection.

Nicholas L. Yan, Mylan Mayer, Arthur A. Melo et al. · 0 citations
Review Open access Sep 2026

Minding the gates: dual cell-autonomous and non-cell-autonomous mechanisms of TBK1 in ALS/FTD

The multifaceted role of TBK1 as a master regulator of proteostasis and inflammatory pathways is discussed, its critical role in maintaining microglial homeostasis is highlighted, and how these convergent functions inform therapeutic strategies for ALS/FTD is explored.

Julie Smeyers, Daniel A. Mordes · 0 citations

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