Open access
Sep 2026
Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum
This work provides a systems-level computational framework linking transcriptomic alterations with predicted metabolic remodeling in GABAergic neurons and generates experimentally testable hypotheses regarding metabolic dysfunction during progression from MCI to AD.
Andrea Angarita-Rodríguez, Johan H. Largo-González, Julián Pérez-Mejía et al.
· Frontiers in Systems Biology · 0 citations