Author

Daniel C. Choi

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Open access Sep 2026

Type 1 interferon perturbates clonal competition by reshaping human blood development.

Inflammation accelerates evolutionary dynamics of hematopoietic stem cells (HSCs) in clonal hematopoiesis and myeloid neoplasms. We studied HSCs, progenitors and immune cells from patients with myeloproliferative neoplasms at baseline and following interferon-α (IFNα) treatment, the only therapy to deplete mutated stem...

Chhiring Lama, Danielle Isakov, Shira Rosenberg et al. · Nature Genetics · 0 citations

Aug 2026

Epigenetic Priming with Azacitidine Prior to Allogeneic Hematopoietic Stem Cell Transplantation for Myeloid Malignancies.

BACKGROUND Relapse remains the leading cause of treatment failure following allogeneic hematopoietic stem cell transplantation (alloHCT) for high-risk myeloid malignancies. Epigenetic dysregulation contributes to leukemogenesis and therapeutic resistance. OBJECTIVE OBJECTIVE: : To investigate whether pre-transplant e...

Mohammad Alhomoud, Franco Castillo Tokumori, N. Chokr et al. · Transplantation and Cellular... · 0 citations