Sequential dengue virus (DENV) infection is thought to induce long-lived protection against dengue. However, little is known about the specificity, phenotype, and repertoire of the enduring B cell response due to limitations in high-throughput methods. We used stabilized DENV envelope (E) dimers as probes for in-depth...
Kelsey E. Lowman, R. Aogo, Sarah C. Smith et al.· medRxiv· 0 citations
Merbecoviruses, closely related to the Middle East respiratory syndrome coronavirus, circulate in hedgehogs throughout Europe and Asia, raising concerns about zoonotic transmission to humans and domestic animals. However, it is not clear how these viruses enter host cells. Here we tested three coronavirus receptors fro...
M. Jin, Victoria A. Jefferson, Zhe Zhao et al.· Nature Microbiology· 0 citations
Hundreds of recall and de novo neutralizing monoclonal antibodies are isolated and characterized after sequential exposures to SARS-CoV-2 variants in ancestral-imprinted humans to reveal the distinct contributions of recall and de novo antibodies to a balanced immune response and underscore the benefit of updated boost...
T. Johnston, Shuk-Hang Li, M. Painter et al.· Nature Immunology· 2 citations
This work provides a framework for extracting microbial signals from host-dominated human metatranscriptomes, enabling the reuse of existing transcriptomic datasets for microbiome-related analyses, including but not limited to microbial translocation studies.
Antonino Colajanni, R. Uricaru, S. Darko et al.· Briefings in Bioinformatics· 0 citations
The dependence of effective variant-specific antibodies on vaccination history is shown which may explain birth-year influence on differential susceptibility to SARS-CoV-2 variants XFG and BA.3.3.2, and it is suggested that vaccination regimens in children should prioritize neutralization breadth.
T. Johnston, Rahul Subramanian, Wakinyan Benhamou et al.· bioRxiv· 0 citations
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