Open access
Sep 2026
Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias
Cardiac autonomic neurons regulate contractility. Autonomic nervous system dysregulation can cause sympathetic overdrive, leading to heart failure, and fatal arrhythmias. Here, we introduce innervated engineered human myocardium (iEHM), a model of neuro-cardiac junctions, constructed by fusing sympathetic neuronal orga...
L. V. Schneider, Michael Gani Setya, Guobin Bao et al.
· Nature Communications · 0 citations