Daniel J. Müller

Load-dependent RGD-context sensing via αV-class integrins reprograms cell adhesion and mechanics

The biochemical and mechanical properties of extracellular matrix proteins govern cell adhesion, mechanics, and migration. How cells use integrins to discriminate between the arginine-glycine-aspartic acid motifs presented by different extracellular matrix proteins, a process central to tissue homeostasis and disease,...