Standard metagenomics resolves microbial communities only in relative terms and at coarse taxonomic resolution, obscuring how individual strains change in absolute abundance and evolve within a host1–6. We present long-read quantiomics (LRQ), a quantitative metagenomics platform coupling long-read sequencing with plasm...
M. O. Din, C. Brennan, Jian-Shu Zhao et al.· bioRxiv· 0 citations
ABSTRACT Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), driven by genetic and environmental determinants. The gut microbiome of people with MS (pwMS) is distinct and influences disease through immunomodulatory metabolite production. Circulating metabolites are altered in pwMS, but...
T. Montgomery, Emily A. Nelson, Lauren A. Downs et al.· mSystems· 0 citations
Dietary response is modulated by gut microbiome composition and that integrated microbiomic-metabolomic analyses can predict drivers of disease worsening in MS, indicate that dietary response is modulated by gut microbiome composition.
T. Montgomery, Emily A. Nelson, Lauren A. Downs et al.· Journal of Immunology· 0 citations
Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.
Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al.· Molecular Systems Biology· 1 citation
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