Open access
Jul 2026
Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development
Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is induced by sterols, oxysterols, and arachidonic acid (AA) through binding pockets in its extracellular cysteine-rich domain (CRD) and 7-transmemb...
M. Dillard, Christina A. Daly, Rojalin Pradhan et al.
· Nature Communications · 0 citations