Technological approaches to tamoxifen nanoformulation: emphasis on modified chitosan-based nanoparticles: a review
Tamoxifen remains a cornerstone in the treatment of estrogen receptor-positive breast cancer, yet its clinical performance is limited by poor aqueous solubility, high lipophilicity, and interindividual variability associated with CYP2D6-mediated formation of its more potent active metabolites. These challenges necessit...