Daniela M. Roth

Assessing Hydrogel Microenvironment Density Effects on Mechanotransduction In Vitro and Bone Regeneration In Vivo.

For bone regeneration, matrix density is a critical determinant of scaffold performance, influencing both mechanical stiffness and biological accessibility, that is, how readily cells interact with and remodel the matrix. Here, we investigated how collagen matrix densification modulates stem cell mechanosensing in vitr...