Open access
Sep 2026
Bridging AI, molecular dynamics, and experiments for mechanism-aware TCR engineering in cancer immunotherapy
This integrated approach establishes a closed-loop, multi-scale design paradigm that combines exploration, mechanistic understanding, and functional validation, providing a promising strategy for the rational development of therapeutic TCRs.
Mario Frezzini, Daniele Narzi
· Frontiers in Chemical Biolog... · 0 citations