Open access
Sep 2026
Type 1 interferon perturbates clonal competition by reshaping human blood development.
Inflammation accelerates evolutionary dynamics of hematopoietic stem cells (HSCs) in clonal hematopoiesis and myeloid neoplasms. We studied HSCs, progenitors and immune cells from patients with myeloproliferative neoplasms at baseline and following interferon-α (IFNα) treatment, the only therapy to deplete mutated stem...
Chhiring Lama, Danielle Isakov, Shira Rosenberg et al.
· Nature Genetics · 0 citations