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Author

Danielle K. Sohai

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Open access Oct 2026

Functional Exhaustion Limits CAR-NK Therapy in Glioblastoma but Can Be Mitigated by Early Repeated Dosing

Abstract With the commercial success of Chimeric Antigen Receptor T (CAR-T) cell therapies in the blood cancer setting, there are increasing numbers of clinical trials evaluating this treatment modality in patients with solid tumors, including brain tumors. Allogeneic CAR-natural killer (NK) cell therapy offers an attr...

Kajal Chaudhry, N. Muniraj, H. Lang et al. · 0 citations
Open access Jul 2026

Targeting DNMT1 augments anti-tumor CD8⁺ T cell function

DNMT1 targeting is established as a promising strategy to counteract CD8⁺ T cell exhaustion and potentiate ICI efficacy and enhances the effector function of melanoma patient-derived tumor infiltrating lymphocytes after prolonged ex vivo expansion.

M. Deshmukh, Danielle K. Sohai, Kamal Obbad et al. · 0 citations

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