Danielle M. Burgenske

Approaches to Optimize Cell Internalization and In Vivo Tumor Homing by Aptamer-drug Conjugates using SELEX

Targeting O6-methylguanine-DNA methyltransferase deficiency in preclinical models of extracranial human cancers with a tumor-selective DNA modifying agent

Temozolomide (TMZ) is an established therapy for gliomas with silencing of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) but is hindered by the frequent development of resistance via loss of mismatch repair (MMR) proteins. To overcome this resistance, a novel 2-fluoroethylating agent, KL-50, was...

Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT

INvestigating SIGnaling network of specific cell subpopulation in Heterogeneous Tissue, a new platform technology combining fluorescence-activated cell sorting with ultra-sensitive mass spectrometry to enable phosphoproteomic characterization of rare and discrete cell subpopulations from fixed tissues, uncovered a glob...