Danish Alam

Mechanistic insights into the inhibition of α-synuclein aggregation by sugar-based nanoparticles.

It is demonstrated that sugar-derived nanoparticles act as potent inhibitors of α-syn aggregation during the lag phase, thereby stabilizing non-toxic conformers and highlighting the promise of sugar-based nanostructures as biocompatible and mechanistically active molecules for modulating synucleopathies associated with...