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Author

Danmeng Li

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Review Jul 2026

Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches.

Structural biology and signaling principles are integrated to explain how MDA5 architecture governs interactions with dsRNA and type 1 interferon (T1-IFN) outputs and outline therapeutic entry points that preserve antiviral defense while constraining chronic T1-IFN signaling.

Opeoluwa F. Iwaloye, Clayton E. Mathews, Dan-Meng Li · 0 citations

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