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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Dannielle D. Engle

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2 papers indexed here

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Sep 2026

Abstract B063: Exploring combination therapies to overcome RAS inhibitor resistance in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, due in large part to limited therapeutic options and the rapid emergence of treatment resistance. Despite the clinical success of recently developed RAS inhibitors (RASi) resistance to these agents , both mutant-specific and pan-RAS,...

Vasiliki I. Pantazopoulou, Casie S. Kubota, W. Jung et al. · 0 citations
Open access Aug 2026

The CA19-9 glycan is a viable target for CAR T cell therapy in pancreatic and other solid tumors.

BACKGROUND & AIMS Chimeric antigen receptor (CAR) T cell therapy for pancreatic ductal adenocarcinoma (PDAC) has been challenging, in part due to the paucity of tumor-specific cell-surface targets. Here, we explored the design feasibility and anti-tumor efficacy of CAR T cells recognizing the CA19-9 glycan, a tumor ant...

Fei-Yan Mo, Austin L. Good, Jayne C. McDevitt et al. · 0 citations

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