Author

Daolin Tang

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Review Open access Sep 2026

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assem...

Yuan-Qiang Lin, Mingran Dai, En-Yong Dai et al. · Advancement of science · 0 citations

Aug 2026

LZTFL1 rewires NADPH-glutathione metabolism to amplify ferroptosis.

Leucine zipper transcription factor-like 1 (LZTFL1) is identified as a key regulator of ferroptosis that rewires glutathione (GSH) metabolism and is highlighted as a potential biomarker and a therapeutic target for enhancing ferroptosis-based cancer therapy.

Xiangfei Xue, Xiao Zhang, Qianjun Zhou et al. · Molecules and Cells · 0 citations

Open access Aug 2026

Metabolic-epigenetic rewiring of CCR5hi monocytes sustains long-term trained immunity against lethal sepsis

Findings identify a lactate-KAT2B-H3K18la epigenetic axis that orchestrates the long-term reprogramming of CCR5hi monocytes, highlighting CCR5hi monocytes as a promising therapeutic target for modulating innate immunity against lethal sepsis.

Lingqi Xu, Wenyan Hao, Yingyi Yang et al. · Science Advances · 0 citations