Open access
Sep 2026
Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis
It is demonstrated that IDH3A is significantly overexpressed in melanoma, primarily due to DNA copy number amplification, and a noncanonical role of IDH3A is uncovered as a nuclear regulator of transcription via YBX1, offering novel insight into metabolic enzyme reprogramming in melanoma.
Juan Ran, Yan-Chun Fang, Sheng-Ming Ruan et al.
· Advancement of science · 0 citations