Open access
Aug 2026
Interferon-stimulated gene signature predicts clinical response to low-dose IL-2 in immune-mediated inflammatory diseases.
OBJECTIVES Low-dose interleukin-2 (IL-2LD) preferentially stimulates regulatory T cells (Treg) over conventional CD4+ T cells (Tconv), controlling inflammation and promoting immune tolerance in autoimmune and other immune-mediated inflammatory diseases. However, IL-2 has pleiotropic functions, and its therapeutic mecha...
N. Tchitchek, M. Rosenzwajg, R. Lorenzon et al.
· Annals of the Rheumatic Dise... · 0 citations