Author

Daren Fearon

2 papers indexed here

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Open access Sep 2026

A resource-efficient structure-based workflow for fragment progression enables parallel hit discovery and validation of functionally diverse modulators of NCS-1 protein–protein interactions

Efficient drug discovery workflows ideally generate data that directly address key translational milestones, including confirmation of target engagement and binding pose, structure–activity relationships (SARs), and biological relevance, within rapid and resource-efficient experimental cycles. Here, we describe a data-...

D. Muñoz-Reyes, K. Fieseler, M. Winokan et al. · Chemical Science · 0 citations

Open access Jul 2026

X‑ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV‑2 Nsp3 Macrodomain (Mac1)

Mac1 is a conserved macrodomain enzyme in the nonstructural protein 3 (Nsp3) of SARS-CoV-2 and is part of the viral replication machinery. Mac1 is a target for small-molecule inhibitors that could ultimately enable new COVID-19 therapeutics to be developed. Here, we report the structure-guided design, synthesis, and Ma...

Xinyu Wang, William T W Butler, James R Donald et al. · Journal of Medicinal Chemist... · 0 citations