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Author

Darren Gilmour

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Open access Oct 2026

A chemigenetic fluorescence lifetime-based biosensor for imaging of ERK activity

Extracellular signal-regulated kinase (ERK) governs many cellular processes, and its spatiotemporal activity dynamics are important for downstream signaling specificity. Existing fluorescent ERK activity biosensors, however, fall short in enabling spectrally multiplexed, spatially resolved, or deep tissue measurements....

Elias Dressler, Rohan S. Eapen, Dennis Pellanda et al. · 0 citations
Open access Sep 2026

Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells

The cell cycle phase is the major source of variability in transcription within a division cycle, and combining this with the analysis of key transcription factors and chromatin modifier state enables accurate prediction of transcriptional output during zygotic genome activation in individual cells.

Max Hess, M. Wyss, Edlyn Wu et al. · 0 citations

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