Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications.
PURPOSE OF REVIEW This review examines the mechanistic, epidemiological and therapeutic evidence underpinning liver integration into the cardiovascular-kidney-metabolic (CKM) construct. For the purposes of this review, we use the term cardiovascular-renal-hepatic-metabolic (CRHM) syndrome to denote this expanded framew...