Darren P. Wallace

Apelin Inhibits Cyst Growth and Improves Kidney Function in Mice with Polycystic Kidney Disease.

CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD.

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are caused by mutations in PKD1, which reduce polycystin-1 (PC1) levels below a critical functional threshold. Normalizing PC1 dosage mitigates disease progression; therefore, we sought to develop a CRISPR activation (CRISPRa) strategy to transcriptiona...

Dysregulated Ferritin and Iron Homeostasis in Autosomal Dominant Polycystic Kidney Disease.

A disruption in ferritin handling and iron homeostasis in PKD is demonstrated, suggesting altered iron trafficking promotes localized oxidative stress and fibrosis contributing to disease progression.

Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease.

Findings reveal that autophagy in MFs is a previously unrecognized driver of cyst expansion and fibrosis in ADPKD and targeting MF-specific autophagy or its upstream regulators may represent a therapeutic strategy to limit cyst growth and fibrosis in ADPKD.