Darsha D. Senevirathne

Enrichment of CD4−CD8− cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease

This study used single-cell RNA sequencing to provide a high-resolution characterization of CD4−CD8− γδ T cells in peripheral blood across healthy Mtb-(non-)sensitized and TB disease pre-/post-treatment cohorts and found an activated and cytotoxic gene signature in γδ T cells of TB disease compared with both healthy co...