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Author

D'Artagnan Greene

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Open access Sep 2026

A structure-based model that describes activation and inactivation of a sodium channel.

While the Hodgkin-Huxley formalism successfully describes sodium channel gating, the molecular origin of its nonlinear voltage dependence remains unclear. We developed a structure-based model of Nav1.4 representing the four voltage-sensing domains, the isoleucine-phenylalanine-methionine (IFM) motif and the S6 gate as...

D'Artagnan Greene, S. Perez, Y. Shiferaw · 0 citations

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