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Dattatraya G. Raut

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Open access Sep 2026

Novel Pyrazole‐4‐Carbaldehyde Derivatives Having Potent COX‐2 Inhibition and Anti‐Tubercular Activity: Microwave‐Assisted Green Synthesis and Molecular Docking

ABSTRACT A series of 1‐(4‐Chorophenyl)‐3Aryl‐1‐H‐pyrazole‐4‐carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR, 1H‐NMR, 13C‐NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds. The newly synthesized Pyrazole aldehydes were eval...

M. Kokane, Dnyandev Bhosale, Dattatraya G. Raut et al. · 0 citations
Aug 2026

A highly efficient one-pot approach for the synthesis of novel 5-amino-4-Cyano-Pyrazoles with promising anti-inflammatory and broad-spectrum antimicrobial activity.

Computer studies provided further support for the observed COX-2 inhibition and indicated favorable pharmacokinetic profiles of the synthesized 5-Amino-4-cyanopyrazole derivatives, highlighting the synthetic efficiency of the developed one-pot protocol and the promising biological potential of the synthesized derivativ...

M. Kokane, Dnyandev Bhosale, Dattatraya G. Raut et al. · 0 citations

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