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Author

David A. Brenner

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Open access Oct 2026

EARLY-ALS: a multicentre study on prodromal amyotrophic lateral sclerosis.

BACKGROUND Neurodegenerative diseases often feature a prolonged phase of subtle changes preceding diagnosis. In amyotrophic lateral sclerosis (ALS), defining this prodromal period is critical for identifying early disease features and intervention windows. METHODS In this case-control study, 475 patients with ALS and...

I. Cordts, A. Galhoz, L. Tzeplaeff et al. · 0 citations
Open access Jun 2026

A rare missense variant impacting NEK1 kinase function is associated with ALS

Findings provide strong genetic and functional evidence for a disease-causing role of NEK1 kinase disruption in NEK1-ALS and provide immediate diagnostic and therapeutic implications, particularly for the functional interpretation of missense variants of uncertain significance and the development of targeted treatment...

David Brenner, Anna Ponomarenko, Iris Petrut et al. · 1 citation

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