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Author

David A. Fox

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Open access Aug 2026

Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation

Introduction CD6 is an immunological synapse-associated receptor that integrates adhesive and signaling cues to shape T-cell activation. We previously showed that, in CD6-humanized mice, the anti-human CD6 monoclonal antibody UMCD6 suppresses disease severity and Th1/Th17 responses in models of autoimmunity, but its me...

K. Maeda, Phillip L. Campbell, Qi Wu et al. · 0 citations
Review Open access Aug 2026

Immunotherapy of cancer without induction of autoimmunity – CD6 as a therapeutic target

Recent work on anti-CD6 as a candidate immunotherapy for cancer as well as relevant advances in the understanding of other aspects of the biology of CD6 are described and the possibility that this approach could avoid the autoimmune complications that are encountered with checkpoint inhibitor treatment of cancer is exp...

David A. Fox, Mikel Gurrea-Rubio · 0 citations
Open access Aug 2026

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis.

Abatacept selectively modulates CD319/SLAMF7-expressing cytotoxic T cells and suppresses associated pro-fibrotic and pro-inflammatory cytokines, particularly in the fibroproliferative subtype, where CD319+ T cell reductions correlate with clinical improvement.

Mikel Gurrea-Rubio, Laura A. Cooney, Kohei Maeda et al. · 0 citations

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