Targeted therapies in systemic lupus erythematosus: mechanistic insights and clinical evidence from phase II and III trials
Systemic lupus erythematosus (SLE) is a complex autoimmune rheumatic disease characterised by autoantibody production and dysregulated B- and T- cell activation, resulting in multisystem involvement. Despite therapeutic advances, persistently active and corticosteroid-dependent disease remain a significant clinical...