The prototype members of the genus Henipavirus, Nipah virus (NiV) and Hendra virus (HeV), cause recurrent zoonotic spillovers with case fatality rates ranging from 40-90% in humans. Currently, there are no approved vaccines or therapeutics for use in humans. Neutralizing antibodies targeting the NiV/HeV F-or G-glycopro...
J. Sims, Risako Gen, Kaitlin R. Sprouse et al.· bioRxiv· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) is refractory to most therapies, including immunotherapies, for which reinvigoration of CD8 T cells through immune checkpoint blockade is insufficient to induce long-term, durable remissions. Direct KRAS inhibitors (KRASi) have shown clinical promise, although acquired resistance...
Li Qiang, Megan T. Hoffman, Jung-Ho Chun et al.· Cell· 0 citations
It is shown that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures, suggesting that some difficult RNA design tasks may be tractable without first solving RNA 3D structure prediction.
J. Townley, W. Kladwang, David Baker et al.· Science· 1 citation
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
RFO formulates binder improvement as a residue-wise mutational search problem, sampling candidate substitutions alternately based on gradient-guided sequence optimization using all-atom structure prediction models and a cycling-based sequence redesign strategy that alternates structure generation with an orthogonal pre...
Odin Zhang, Jia-Qi Wang, T. R. Thompson et al.· bioRxiv· 0 citations
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
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