Processivity is essential for gene expression: Escherichia coli RNA polymerase (RNAP) must transcribe 10+ kbp operons without failure, yet backtrack-induced long-lived pauses threaten premature termination. Gre factors stimulate transcript cleavage to rescue backtracked RNAP, whereas NusA and NusG, which bridge the exp...
Luca Buccolieri, Bing Wang, Pim P. B. America et al.· bioRxiv· 0 citations
Human noroviruses (HuNoVs) are the leading global cause of acute gastroenteritis, yet no vaccines or antiviral therapies are currently approved. The non-structural protein NS3 is a membrane-bound AAA+ ATPase of superfamily 3 (SF3) with multiple proposed roles in the norovirus replication cycle. However, the structure...
Meryl Haas, T. Hoeksma, J. Mills et al.· Nature Communications· 0 citations
These findings establish a two-pronged mode of coronavirus polymerase inhibition by CMX521, and suggest a second inhibitory mechanism for CMX521 when the coronavirus polymerase is associated with the viral helicase.
Asif Rakib, Calvin J. Gordon, Thomas K. Anderson et al.· Journal of Biological Chemis...· 0 citations
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