Author

David E. Heinrichs

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Open access Aug 2026

The RND family efflux pump FemT contributes to lipid homeostasis in Staphylococcus aureus”

The constructed FemT exhibited impaired growth on exposure to saturated and unsaturated fatty acids, and exposure to subinhibitory 50 µM palmitic acid promoted accumulation of reactive oxygen species, reduced respiratory activity, and altered membrane function and morphology, consistent with a general role in efflux of...

A. Thukral, Camryn Bonn Dunbar, Jamie N Halucha et al. · bioRxiv · 0 citations

Open access Jul 2026

The oxidative stress regulator, PerR, is required for staphyloferrin B-mediated iron acquisition in Staphylococcus aureus

The importance of the PerR function to S. aureus was highlighted by examination of over 8,000 human bloodstream isolates of S. aureus, showing that the PerR sequence was highly conserved, and these findings demonstrate the importance of PerR in providing an additional level of regulation of Fe homeostasis beyond Fur-de...

Alexander A Sheikh, Ronald S. Flannagan, Nathan J Nicholson et al. · Journal of Bacteriology · 0 citations