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Author

David E. James

2 papers indexed here

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Open access Sep 2026

Personalized phosphoproteomics establish mTORC1 as a regulator of exercise-induced insulin sensitization in human skeletal muscle

Exercise enhances skeletal muscle insulin sensitivity, but the signaling mechanisms responsible are poorly understood. Understanding them may open new therapeutic avenues for individuals with limited exercise capacity. Here, we used rapamycin to inhibit mTORC1 in combination with exercise and insulin stimulation in hea...

Magnus R. Leandersson, H. Huckstep, J. Onslev et al. · 0 citations
Review Jul 2026

Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess.

Obesity-related type 2 diabetes (T2D) is currently defined by insulin resistance and impaired insulin secretion. Sulfonylureas, thiazolinediones, and insulin are effective at lowering glycemia yet have not consistently translated into improved long-term outcomes. In contrast, recent interventions often produce metaboli...

M. Prentki, Christopher J. Nolan, David E. James et al. · 0 citations

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