Author

David E. Kaplan

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Open access Sep 2026

Validation of next-generation sequencing-derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma

Liquid biopsy can transform oncology practice through early detection and real-time monitoring of cancer progression and response to treatment. Circulating cell-free tumor RNA offers promise as a novel and emerging alternative to circulating cell-free tumor DNA for detecting the presence and understanding the biology o...

Daniel Zezulinski, M. Hoteit, David E. Kaplan et al. · Oncology Report · 0 citations

Open access Aug 2026

Multi-ancestry sequencing analysis in 293,141 participants identifies predisposition DNA repair genes associated with HCC risk.

Rare variants in MSH6 and BRCA2 are significantly associated with increased HCC risk, revealing a previously unconfirmed role for DNA repair genes in HCC susceptibility across ancestrally diverse populations and may inform genetic risk stratification and surveillance strategies.

A. Garófalo, Perapa Chotiprasidhi, Josephine P. Johnson et al. · JHEP Reports · 0 citations