Author

David E. Stec

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Review Open access Sep 2026

A Matter of Balance: Heme Oxygenase-1 at the Crossroads of Healthy and Pathological Aging.

Increasing life expectancy has led to a growing prevalence of age-related disorders, including dementia, cardiovascular disease, frailty, osteoporosis, sarcopenia, and cancer. Heme oxygenase-1 (HO-1), a stress-inducible enzyme that degrades heme into carbon monoxide (CO), biliverdin which is then reduced to bilirubin b...

Sally Wahba, David E. Stec · Archives of Biochemistry and... · 0 citations

Open access Sep 2026

The Human PNPLA3I148M Polymorphism Alters the Renal Kinome and Transporters to Cause Hyperfiltration and Hypertension

The patatin‐like phospholipase domain‐containing protein 3 (Pnpla3) I148M polymorphism is a well‐established genetic determinant of metabolic dysfunction‐associated steatotic liver disease (MASLD), and emerging evidence links it to chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the mechanisms u...

Gertrude Arthur, Michael I. Adenawoola, Sally Wahba et al. · FASEB bioAdvances · 0 citations