Author

David Fedida

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Open access Oct 2026

Structural and kinetic mechanisms of state-dependent potassium channel inhibition

The KCNQ1 (Kv7.1) potassium ion (K+) channel plays a critical role in cardiac repolarization, while loss- or gain-of-function mutations increase the risk of life-threatening arrythmias and sudden death. Like many channels, KCNQ1 exhibits state-dependent pharmacological properties with inhibitors such as UCL2077 display...

E. Kyriakis, Agnese Roscioni, Jodene Eldstrom et al. · Science Advances · 0 citations

Open access Sep 2026

Functional heterogeneity of arrhythmogenic KCNQ1 S1 mutants reveals dependence on the number of KCNE1 subunits in the IKs channel complex.

BACKGROUND A cluster of closely spaced residues located at the extracellular end of the S1 transmembrane domain in KCNQ1 (Q1, residues 140-147) harbors six mutations associated with both gain- and loss-of-function (GoF and LoF) arrhythmic diseases. Whether severity of the mutation phenotype is affected by the stoichiom...

Michael Tian, M. Pourrier, Magnus Chan et al. · Heart Rhythm · 0 citations