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Author

David Grant

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Open access Sep 2026

Discovery and Optimization of Imidazothiazole Carboxamides as Novel Anti-Tuberculosis Agents

Screening of the open-access CRESTdb small-molecule library identified the imidazothiazole carboxamide sCQG200 (1) as an initial hit, with activity against H37Rv and Erdman Mycobacterium tuberculosis strains in cholesterol-containing medium (MIC90= 6.88 µM and 4.48 µM, respectively) and against intracellular Mtb (EC50=...

Leo Meng, David Grant, Han Xie et al. · 0 citations

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