Author

David H. Gutmann

2 papers indexed here

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Aug 2025

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actionable fusions, the proto-oncogene is the drug target, the contributions to oncogenicity of the fusion partner have large...

Anna Borgenvik, Sean A. Misek, Daniel Christen et al. · bioRxiv · 1 citation

Open access Aug 2026

Harmonizing Multi-Institutional Clinical Documentation Using Natural Language Processing in Neurofibromatosis Type 1 (NF1)

Background and Objectives. Machine learning (ML) and natural language processing (NLP) approaches are increasingly used to support nuanced phenotyping, surveillance, and trial readiness using electronic health records (EHRs) in neurological disease. However, inconsistent clinical documentation limits data harmonization...

Stephanie M. Morris, Levi Kaster, S. Amagai et al. · Neurology Clinical Practice · 0 citations