David H. Johnson

Cholesterol differentially regulates α-synuclein binding across membrane packing regimes

α-Synuclein (αSyn) is an intrinsically disordered protein that preferentially binds anionic membranes with lipid packing defects. Cholesterol is an abundant membrane component that regulates packing and organization within membranes, yet its effect on αSyn binding remains unclear, as prior studies report both cholester...