Author

David J. Granville

2 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Sep 2026

Extracellular granzyme K links inflammatory signaling to nucleotide metabolism, driving epithelial hyperproliferation and reprogramming

Granzymes (Gzms) are a family of serine proteases that have been traditionally studied as cytotoxic mediators of lymphocyte-mediated target cell death. However, increasing evidence suggests that during inflammation Gzms can accumulate in the extracellular milieu and contribute to various pathologies depending on the...

K. Richardson, Jeffrey S. Tang, A. Aubert et al. · Cell Death & Disease · 0 citations

Review Open access Aug 2026

Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities

Neurodegenerative diseases are increasingly recognized as disorders shaped not only by intrinsic neuronal vulnerability, but also by chronic neuroinflammation mediated by maladaptive neuroimmune signaling. Granzymes, a family of serine proteases classically studied for their cytotoxic roles in anti-viral and anti-tumor...

Hyung-Suk Yoo, Philip Yu, Ceres Zhou et al. · Acta Neuropathologica · 0 citations