David J. van Dongen

Catalytic properties of the integral membrane RAS protease Rce1.

The integral membrane protease Rce1 cleaves prenylated CaaX proteins, including all RAS GTPases, as part of their post-translational maturation. This cleavage, which removes the -aaX residues, is necessary for the proper cellular location and signaling properties of RAS and its oncogenic forms. Poor biochemical stabili...