Clinical and Molecular Profiles of Treatment-Emergent Small Cell Neuroendocrine Prostate Cancers in the Era of Intensified Systemic Therapies.
Variant histologic features can emerge in therapy-resistant prostate cancers, with treatment-emergent small-cell neuroendocrine carcinomas (t-SCNC) the most common. Here we report clinical, histopathological, and genomic features of 126 t-SCNCs and 14 other treatment-emergent variant histologies. This retrospective mul...