David J. Wrucke

Macroscopic to ultrastructural analyses identify the loss of myofibrils as the primary mediator of ageing‐ and disuse‐induced muscle fibre atrophy

Abstract Ageing and disuse are two of the most clinically relevant conditions associated with the loss of skeletal muscle mass, yet the ultrastructural adaptations that drive these losses remain poorly defined. Indeed, even the most basic questions, such as whether radial atrophy of muscle fibres is driven primarily by...